The Eating Disorder Recovery Podcast

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September 27, 2017  

Defining Restriction. Defining Unrestricted Eating

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In this podcast, Tabitha talks about restriction, and unrestricted eating. Restrictive eating disorders such as Anorexia are often misrepresented as total restriction and not eating. This is often not the case. Many people with Anorexia can eat seemingly "normal" amounts of food and still be operating under rules of restriction. The key is understanding that unrestricted eating is required in order to allow the brain and body to fully exit the Anorexia response. 

Redefining how you think of restriction is often the key to understanding what unrestrictive eating means for you 

 

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September 20, 2017  

Dr G: Tummy Troubles in Eating Disorder Recovery

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Tabitha talks to Dr. Jennifer Gaudiani about all things gastrointestinal in eating disorder recovery! We talk about bowel movements, irritable bowel syndrome, delayed gastric emptying, and so much more! 

 

 

Medical Minute Videos: 
Blog Posts: 
 
 
 
 
 
 
AED Guidelines: 
September 14, 2017  

Science: Variants in neuropeptide signaling are associated with disordered eating behaviors

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In this podcast Tabitha Farrar talks to Micheal Lutter about the recently published paper titled: Novel and ultra-rare damaging variants in neuropeptide signaling are associated with disordered eating behaviors

 

From the paper:

Abstract

Objective

Eating disorders develop through a combination of genetic vulnerability and environmental stress, however the genetic basis of this risk is unknown.

Methods

To understand the genetic basis of this risk, we performed whole exome sequencing on 93 unrelated individuals with eating disorders (38 restricted-eating and 55 binge-eating) to identify novel damaging variants. Candidate genes with an excessive burden of predicted damaging variants were then prioritized based upon an unbiased, data-driven bioinformatic analysis. One top candidate pathway was empirically tested for therapeutic potential in a mouse model of binge-like eating.

Results

An excessive burden of novel damaging variants was identified in 186 genes in the restricted-eating group and 245 genes in the binge-eating group. This list is significantly enriched (OR = 4.6, p<0.0001) for genes involved in neuropeptide/neurotrophic pathways implicated in appetite regulation, including neurotensin-, glucagon-like peptide 1- and BDNF-signaling. Administration of the glucagon-like peptide 1 receptor agonist exendin-4 significantly reduced food intake in a mouse model of ‘binge-like’ eating.

Conclusions

 

These findings implicate ultra-rare and novel damaging variants in neuropeptide/neurotropic factor signaling pathways in the development of eating disorder behaviors and identify glucagon-like peptide 1-receptor agonists as a potential treatment for binge eating.

 

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0181556

 

Support this podcast via Patreon!

You can support this podcast and ensure the continuation of it by pledging a patreon donation here: https://www.patreon.com/Eating_Disorder_Recovery_Podcast

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Subscribe to these podcasts in iTunes: https://itunes.apple.com/us/podcast/eating-disorder-recovery-podcast/id1138563928?mt=2

Community Links:

Adults in recovery community Slack Group: http://tabithafarrar.com/slack-forum/

Facebook Community: https://www.facebook.com/EDMealSupport/