The Eating Disorder Recovery Podcast

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Male vs Female Treatment Experiences in Eating Disorder Treatment

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In this podcast Tabitha talks to Philipa Hay about recent research that looked into male autobiographies of eating disorders and recovery experiences. 

Link to the full research paper --> https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5485468/

Study Abstract

Eating disorders are increasingly recognized as a problem for men but help-seeking is low and little is known about their treatment experiences. This paper sought to determine the treatment experiences of men who have suffered from an eating disorder using autobiographical data. Inclusion criteria were autobiographies of men who had experienced an eating disorder and sought any form of treatment for this, written in the English language, published between 1995 and 2015, and available for purchase in 2016. The search resulted in six books that were thematically analyzed. Analysis of data resulted in two broad themes (1. Positive experiences; 2. Negative experiences) with sub-themes. With regards to the first theme, factors such as concern of staff members, therapist’s expertise (in treating eating disorders in men), and a collaborative treatment approach were considered favorable for treatment. In contrast to the first theme, apathy of staff members, the authors’ own negative preconceptions, treatment providers being perceived as prioritizing financial concerns, perceived as incompetent and judgmental behavior of therapist(s), and time limitations of sessions were considered unfavorable treatment experiences. In this study, the perceived success of treatment depended on therapist’s features and the form of treatment provided. Further research examining these is indicated.

 

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September 14, 2017  

Science: Variants in neuropeptide signaling are associated with disordered eating behaviors

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In this podcast Tabitha Farrar talks to Micheal Lutter about the recently published paper titled: Novel and ultra-rare damaging variants in neuropeptide signaling are associated with disordered eating behaviors

 

From the paper:

Abstract

Objective

Eating disorders develop through a combination of genetic vulnerability and environmental stress, however the genetic basis of this risk is unknown.

Methods

To understand the genetic basis of this risk, we performed whole exome sequencing on 93 unrelated individuals with eating disorders (38 restricted-eating and 55 binge-eating) to identify novel damaging variants. Candidate genes with an excessive burden of predicted damaging variants were then prioritized based upon an unbiased, data-driven bioinformatic analysis. One top candidate pathway was empirically tested for therapeutic potential in a mouse model of binge-like eating.

Results

An excessive burden of novel damaging variants was identified in 186 genes in the restricted-eating group and 245 genes in the binge-eating group. This list is significantly enriched (OR = 4.6, p<0.0001) for genes involved in neuropeptide/neurotrophic pathways implicated in appetite regulation, including neurotensin-, glucagon-like peptide 1- and BDNF-signaling. Administration of the glucagon-like peptide 1 receptor agonist exendin-4 significantly reduced food intake in a mouse model of ‘binge-like’ eating.

Conclusions

 

These findings implicate ultra-rare and novel damaging variants in neuropeptide/neurotropic factor signaling pathways in the development of eating disorder behaviors and identify glucagon-like peptide 1-receptor agonists as a potential treatment for binge eating.

 

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0181556

 

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Challenging intake guidelines — Dr Graham Redgrave

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Tabitha Farrar talks to Dr Graham Redgrave about the research done at Johns Hopkins looking into higher weights and a faster rate of refeeding patients with Anorexia in an inpatient hospital setting. The conversation includes:

  • Refeeding intakes, traditional expectations versus new developements
  • Problems with low target weights
  • Relapse prevention programs
  • Lower rate of relaspe for patients who reach higher BMIs in treatment
  • The case for higher caloric intakes once the risk of refeeding syndrome is past
  • What refeeding syndrome is, and research around this
  • How and when treatment fails patients. 
  • Why we need to challenge the current guidelines pertraining to refeeding intakes

 

 

Link to the orginal study: https://www.ncbi.nlm.nih.gov/pubmed/25625572

 

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